Mechanistic-enriched models: integrating transcription factor networks and metabolic deregulation in cancer

metabolic syndrome and mitochondrial transcription factor a

Expression and Clinical Significance of Activating Transcription Factor 3 in Human Breast Cancer

  Objective(s): Breast cancer is the most common type of cancer among women worldwide. This study investigated the expression and clinical significance of activating transcription factor 3 (ATF3) in human breast cancer and its relationship with the clinical outcome of breast cancer.   Materials and Methods : ATF3 expressions were detected in 114 primary breast cancer tissues and ...

Dynamic Transcription Factor Networks in Epithelial-Mesenchymal Transition in Breast Cancer Models

The epithelial-mesenchymal transition (EMT) is a complex change in cell differentiation that allows breast carcinoma cells to acquire invasive properties. EMT involves a cascade of regulatory changes that destabilize the epithelial phenotype and allow mesenchymal features to manifest. As transcription factors (TFs) are upstream effectors of the genome-wide expression changes that result in phen...

Stochastic differential equations and integrating factor

The aim of this paper is the analytical solutions the family of rst-order nonlinear stochastic differentialequations. We dene an integrating factor for the large class of special nonlinear stochasticdierential equations. With multiply both sides with the integrating factor, we introduce a deterministicdierential equation. The results showed the accuracy of the present work.

The Integrating Factor Method in Banach Spaces

The so called integrating factor method, used to find solutions of ordinary differential equations of a certain type, is well known. In this article, we extend it to equations with values in a Banach space. Besides being of interest in itself, this extension will give us the opportunity to touch on a few topics that are not usually found in the relevant literature. Our presentation includes var...